Instruct patients to discontinue Contrave and consult a healthcare provider if they develop an allergic or anaphylactoid/anaphylactic reaction (e.g., skin rash, pruritus, hives, chest pain, edema, or shortness of breath) during treatment.
In vitro studies suggest that paroxetine, sertraline, norfluoxetine, fluvoxamine, and nelfinavir inhibit the hydroxylation of bupropion.
Copay Cards, typically offered by pharmaceutical companies, co-pay cards are designed to help people with private insurance for the co-payments required to obtain their prescriptions at the pharmacy.
It may increase your risk of seizures.Bupropion (IC50.3 mcM) and its metabolites, hydroxybupropion (IC50 82 mcM) and threohydrobupropion and erythrohydrobupropion (1:1 mixture; IC50.8 mcM inhibited the renal organic transporter OCT2 to a clinically relevant level.For the findings of lvoto and VSD, the studies were limited by the small number of exposed cases, inconsistent findings among studies, and the potential for chance findings from multiple comparisons in case control studies.Patients should be advised that if they previously used opioids, they may be more sensitive to lower doses of opioids and at risk of accidental overdose should they use opioids after Contrave treatment is discontinued or temporarily interrupted.Increases in Serum Creatinine In the one-year controlled trials of Contrave, larger mean increases in serum creatinine from baseline to trial endpoint were observed in the Contrave group compared with the placebo group (0.07 mg/dL and.01 mg/dL, respectively) as well as from baseline.Animals Studies in rodents and primates have shown that bupropion exhibits some pharmacologic actions common to psychostimulants.The following information is available for the individual constituents: Naltrexone Limited information is available for naltrexone in patients with moderate to severe renal impairment.Such monitoring should include daily observation by families and caregivers.
Have or have had an eating disorder called anorexia (eating very little) or bulimia (eating too much and vomiting to avoid gaining weight).In rats, bupropion produced amphetamine-like and cocaine-like discriminative stimulus effects in drug discrimination paradigms used to characterize the subjective effects of psychoactive drugs.Each tablet contains the following inactive ingredients: microcrystalline cellulose, hydroxypropyl cellulose, lactose anhydrous, L-cysteine hydrochloride, crospovidone, magnesium stearate, hypromellose, edetate disodium, lactose monohydrate, colloidal silicon dioxide, Opadry coupons for free dominos pizza II Blue and FD C Blue #2 aluminum lake.Hepatic Impairment Contrave has not been evaluated in subjects with hepatic impairment.Do not take Contrave with high-fat meals.The majority of patients were treated with Contrave 32 mg/360 mg total daily dose.Rats do not form appreciable quantities of the major human metabolite, 6-beta-naltrexol; therefore, the potential reproductive toxicity of the metabolite in rats is not known.Following bupropion administration, more than 90 of the exposure is a result of metabolites.One trial (N793) evaluated patients participating in an intensive behavioral modification program and another trial (N 505) evaluated patients with type 2 diabetes.Blood pressure and pulse should be measured prior to starting therapy with Contrave and should be monitored at regular intervals consistent with usual clinical practice, particularly among patients with controlled hypertension prior to treatment see Dosage and Administration (.1 ).Do not take more than 2 tablets in the morning and 2 tablets in the evening.